Figure 4.

The teNK cell phenotype can be reversed. (A) Heat map of z-scores of gene expression by hNK cells and teNK cells of genes related to NK cell inhibitory signaling. Hierarchical clustering was used to order the genes. (B) Relationship map of receptor-ligand pairs between teNK cells and K14+ or K14 cells as identified by the iTalk algorithm. (C–E) Normalized colony count from antibody-treated control assays and teNK cell–MMTV-PyMT tumor cluster coculture assays. Mean with SEM is represented. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001 by Kruskal–Wallis test.

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