Schematic illustration of MT-mediated pathfinding in complex 3D environments. Left panel: DCs extend multiple protrusion when navigating through the interstitium. In order to maintain cell coherence, side protrusions have to be retracted. The mechanistic basis of coordinating multiple protrusions in complex 3D environments is not understood (red question mark). Right panel: To coordinate multiple protrusions and avoid cell entanglement, MTs depolymerize (dashed red lines) and release Lfc, which leads to actomyosin activation and retraction of competing protrusions (dashed red arrow).