Summary of the identified asymmetric E-cadherin mechanoresponse during mitosis. Mitotic rounding increases tensile forces on adhesions between mitotic cells and their neighbors, resulting in accumulation of vinculin at mitotic junctions that originates selectively from cells neighboring the mitotic cell. This mechanoresponse in the mitotic neighbors is sufficient to reinforce mitotic junctions and maintain epithelial integrity, while the absence of junctional vinculin recruitment in the mitotic cell is essential for cells to successfully undergo mitotic rounding. cat, catenin.