Figure 3.
The kinetics of annexin trafficking are changed in ANO5-KO fibers.(A–D) Time courses of annexin fluorescence as a function of time after injury were fitted to the sum of two exponentials (black lines). Amplitudes, A, and time constants, τ, are shown for the fast and slow components of the curves. AUCs for individual WT or KO fibers are also shown. Data were compared for WT or ANO5-KO fibers expressing ANXA1 (A), ANXA2 (B), ANXA5 (C), and ANXA6 (D). ANXA1: ANO5-KO n = 18 fibers from three mice, WT n = 14 fibers from two mice; ANXA2: ANO5-KO n = 42 fibers from five mice, WT n = 37 fibers from five mice; ANXA5: ANO5-KO n = 36 fibers from four mice, WT n = 29 fibers from three mice; ANXA6: ANO5-KO n = 20 fibers from three mice, WT n = 31 fibers from four mice. Data are mean ± SEM. *, P < 0.05.

The kinetics of annexin trafficking are changed in ANO5-KO fibers. (A–D) Time courses of annexin fluorescence as a function of time after injury were fitted to the sum of two exponentials (black lines). Amplitudes, A, and time constants, τ, are shown for the fast and slow components of the curves. AUCs for individual WT or KO fibers are also shown. Data were compared for WT or ANO5-KO fibers expressing ANXA1 (A), ANXA2 (B), ANXA5 (C), and ANXA6 (D). ANXA1: ANO5-KO n = 18 fibers from three mice, WT n = 14 fibers from two mice; ANXA2: ANO5-KO n = 42 fibers from five mice, WT n = 37 fibers from five mice; ANXA5: ANO5-KO n = 36 fibers from four mice, WT n = 29 fibers from three mice; ANXA6: ANO5-KO n = 20 fibers from three mice, WT n = 31 fibers from four mice. Data are mean ± SEM. *, P < 0.05.

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