Figure 3. Insulin SG properties and... | Rockefeller University Press

Figure 3.

$Insulin SG properties and distance distributions. (A) Volume fraction (percentage) of segmented organelles for all analyzed cells. (B) 3D rendering of one β cell with plasma membrane (transparent gray), insulin SGs (orange), Golgi apparatus (green), and nucleus (yellow). Scale: cube with a side length of 1 µm. (C) Diameter and volume distributions of insulin SGs of all seven analyzed cells (blue, low-glucose cells; orange, high-glucose cells). Horizontal and vertical lines signify the mean and the interquartile range, respectively. (D) Distribution of the distance of insulin SGs to the plasma membrane (PM) for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρPM represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively. (E) Distribution of the distance of insulin SGs to the nucleus for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρNuc represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively. (F) Distribution of the distance of insulin SGs to the Golgi apparatus for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρGolgi represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively.$

Insulin SG properties and distance distributions. (A) Volume fraction (percentage) of segmented organelles for all analyzed cells. (B) 3D rendering of one β cell with plasma membrane (transparent gray), insulin SGs (orange), Golgi apparatus (green), and nucleus (yellow). Scale: cube with a side length of 1 µm. (C) Diameter and volume distributions of insulin SGs of all seven analyzed cells (blue, low-glucose cells; orange, high-glucose cells). Horizontal and vertical lines signify the mean and the interquartile range, respectively. (D) Distribution of the distance of insulin SGs to the plasma membrane (PM) for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρ_PM represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively. (E) Distribution of the distance of insulin SGs to the nucleus for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρ_Nuc represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively. (F) Distribution of the distance of insulin SGs to the Golgi apparatus for one representative low-glucose (blue) and one high-glucose (orange) cell with random distributions ρ_Golgi represented by a black line. Red dotted and black dotted lines represent actual and random cumulative distributions, respectively.