Contractile properties of lamin A/C haploinsufficient hiPSC-CMs. (A) Representative measurements of cellular displacement during contraction of hiPSC-CM monolayers electrically paced at 1 Hz. (B) Representative quantifications of cell contractility from analyses of optical recordings. Differences versus mutant were calculated by one-way ANOVA with post hoc Holm–Sidak binary comparisons (*, P < 0.05; n = 5–6 FOVs; average ± SEM). (C) Representative measurements of twitch force during contraction of 3D-EHTs electrically paced at 1 Hz. (D) Representative quantifications of tissue contractility from analyses of optical recordings. Differences versus mutant were calculated by one-way ANOVA with post hoc Holm–Sidak binary comparisons (*, P < 0.05; **, P < 0.01; ***, P < 0.001; n = 4–5 3D-EHTs; average ± SEM).