Proposed model to explain the role of RAB6 in post-Golgi secretory pathway. All RAB6 effectors associated to post-Golgi secretion, myosin II, KIF5B, and ELKS/RAB6IP2, are involved in the secretion of various cargos. The different events can be envisioned as follows. RAB6 is present on CD59-, TNFα-, and ColX-containing vesicles exiting the Golgi complex. Myosin II is implicated in the fission of these vesicles from Golgi membranes (Miserey-Lenkei et al., 2010). Vesicles are transported to the plasma membrane in a KIF5B-dependent manner (Grigoriev et al., 2007; Miserey-Lenkei et al., 2010), and ELKS ensures their docking to exocytic hotspots close to FAs (Grigoriev et al., 2007, 2011).