Figure 8.
LIN-65 targets a trimeric ARLE-14/LIN-65/MET-2 complex to heterochromatin to form foci. (A) The essential role of the unstructured protein LIN-65 for MET-2 focus formation on heterochromatic loci, and its role in import and stabilization, are shown. MET-2–mediated H3K9me2 is necessary for repeat and tissue specific gene repression. (B) The repercussions of LIN-65 loss are shown.