The photoreceptor PMP compartmentalization code. In the absence of interactions with chaperones, PMPs tend to distribute according to a few simple rules. Positive charge near any lipid moiety leads to synaptic enrichment. Myristoylated proteins with any charge and neutral prenylated proteins slightly favor the ciliary OS. All others are distributed like unmodified EGFP (A). To achieve “super” enrichment of the OS or synapse compartments, active mechanisms to enrich or deplete the ciliary OS must come into play (B).