Figure 4.
Figure 4. Live imaging of LifeAct;Myo5b KO–derived enteroids showed inclusion formation through endocytosis of the apical membrane. Enteroids generated from the proximal small intestine (duodenum) of neonatal LifeAct;Myo5b KO mice were imaged overnight at 37°C with 5% CO2 to examine whether inclusions formed from internalization of the apical membrane. Confocal imaging of LifeAct;Myo5b KO–derived enteroids showed inclusions (red and green arrows) forming from endocytosis of the brush border followed by internalization into enterocytes. Scale bars = 25 µm.

Live imaging of LifeAct;Myo5b KO–derived enteroids showed inclusion formation through endocytosis of the apical membrane. Enteroids generated from the proximal small intestine (duodenum) of neonatal LifeAct;Myo5b KO mice were imaged overnight at 37°C with 5% CO2 to examine whether inclusions formed from internalization of the apical membrane. Confocal imaging of LifeAct;Myo5b KO–derived enteroids showed inclusions (red and green arrows) forming from endocytosis of the brush border followed by internalization into enterocytes. Scale bars = 25 µm.

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