Model of autophagosome–vacuole fusion. Atg14 in the PI3-kinase complex I is required to produce PI3P on the autophagosome to allow Ypt7 recruitment. The R-SNARE Ykt6 localizes to autophagosomes; the Q-SNAREs Vam3, Vam7, and Vti1 localize to the vacuole. With the help of Ypt7 on both the autophagosome and the vacuole and the HOPS tethering complex, trans-SNARE complex formation is promoted and allows autophagosome–vacuole fusion.