Figure 5.
Figure 5. Nucleotide-dependent conformational changes in the Vps1 GG structures. (A) Superposition of Vps1 GGGMPPCP (pale blue) and GGGDP (pink). For ease of visualization, residues 270–299 have been omitted from both structures. (B) Superposition of GGGDP.AlF4- (gold) and GGGDP (pink). As in A, residues 270–299 have been omitted. (C) An alternative view of the superposition shown in A. (D) Detail of the conformational shifts at the bases of the sheets of the core GTPase fold that bring Y126, W114, Y159, and I86 into alignment in GGGMPPCP (blue) to create a hydrophobic ridge.

Nucleotide-dependent conformational changes in the Vps1 GG structures. (A) Superposition of Vps1 GGGMPPCP (pale blue) and GGGDP (pink). For ease of visualization, residues 270–299 have been omitted from both structures. (B) Superposition of GGGDP.AlF4- (gold) and GGGDP (pink). As in A, residues 270–299 have been omitted. (C) An alternative view of the superposition shown in A. (D) Detail of the conformational shifts at the bases of the sheets of the core GTPase fold that bring Y126, W114, Y159, and I86 into alignment in GGGMPPCP (blue) to create a hydrophobic ridge.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal