Loss of E-cadherin and DDR1 correlates with high levels of centrosome amplification in breast cancer. (A) Quantification of centrosome numbers in a panel of breast cancer cell lines. (B) Western blot analysis of E-cadherin, DDR1, and HSET expression in breast cancer cell lines. Red asterisk marks the cell lines with high levels of centrosome amplification. (C) Quantification of centrosome clustering in metaphase and cytokinesis in cells with high levels of centrosome amplification. Error bars represent mean ± SD from three independent experiments.