Macrophage engulfment of speck-containing pyroptotic debris. (A) Time-lapse imaging of Tg(HSE:asc-mKate2, mpeg1:EGFP) larva at 17 hphs shows macrophage engulfing a speck (white arrowhead). (A′) Enlarged view of single plane with brightfield merge showing phagocytic cup (boxed in yellow). (B) Second time-lapse imaging of Tg(HSE:asc-mKate2, mpeg1:EGFP) larvae at 17 hphs, showing degradation of speck within phagosome (white arrowhead). Full time-lapses are included in Video 7. Bars, 30 µm.