Model of cluster formation of KSHV genomes. Shown is a model depicting LANA1 tethering KSHV DNAs together through their TRs. The TRs, 801 bp in length, are blue lines wrapping nucleosomes with the orange segment representing the minimal replication element (MRE) with its three binding sites for the C termini of LANA1 dimers (Hellert et al., 2015). Three nucleosomes per TR accommodate the range of lengths of 192–277 bp per nucleosome used by Chodaparambil et al. (2007), who found that the N terminus of LANA1 on binding the faces of nucleosomes promotes their compaction into a 30-nm fiber (bottom). These compacted fibers have the C termini of LANA1 molecules bound to one KSHV genome’s TRs, with their N termini bound to the nucleosomes on the TRs of other genomes.