Model for regulating dynein-dependent spindle movement. Images are from a cell expressing GFP-tubulin. Cartoons depict the predicted localization of dynein and its regulators during (1) the arrival of the plus end and the cortex, (2 and 3) the initiation of lateral microtubule sliding and spindle movement, (4) the switch to depolymerization during sliding, and (5) termination of sliding by loss of microtubule binding.