Figure 2.

Caspase-2 is cleaved in the nucleolus. (A) HeLa cells treated with or without camptothecin (0, 50, 100, or 200 µM) for 16 h were fractionated into the cytosol, nucleoplasm, and nucleolus and immunoblotted for caspase-2, GAPDH (cytosol), or fibrillarin (nucleolus). (B) HeLa cells treated with or without camptothecin (200 µM) for 16 h were fractionated into the cytosol and nucleolus and immunoblotted for caspase-3, caspase-2, or fibrillarin (nucleolus).

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