WDR91 is important for postnatal development in mice. (A) Representative images of Wdr91f/f and Wdr91f/f cKO mice and their brains at postnatal day 10 (P10) and P21. (B) Body weight of Wdr91f/f and Wdr91f/f cKO mice at P0, P10, and P21. (C) Brain weight of Wdr91f/f and Wdr91f/f cKO mice at P0, P10, and P21. (D) Survival curve of postnatal Wdr91f/f and Wdr91f/f cKO mice. (E) Representative images of the granular neurons in the hippocampus of Wdr91f/f and Wdr91f/f cKO mice at P21. Neurites and cell bodies were revealed by Golgi staining of the brain sections. Bars, 100 µm. (F) Quantification of the cumulative length of the dendritic processes of the hippocampal neurons in Wdr91f/f and Wdr91f/f cKO mice at P10 and P21. (G) Quantification of the dendritic branches of the hippocampal neurons in Wdr91f/f and Wdr91f/f cKO mice at P10 and P21 with Sholl analysis. (F and G) ≥30 neurons from three mouse brains were scored. For all quantifications, error bars represent SEM. n indicates the number of mice analyzed. **, P < 0.01; ***, P < 0.001.
