Figure 8.
Figure 8. Relative expression of GAP-43 after sciatic nerve injury. (A and B) Representative images (A) and quantitative analysis (B) show increased GAP-43 expression in snph KO DRG neurons. snph KO and WT littermates (9 wk old) were subjected to a left-sided sciatic nerve injury. Both injured ipsilateral and uninjured contralateral L5 DRGs of WT and snph KO mice were co-immunostained with antibodies against GAP-43, βIII-tubulin, and DAPI 3 d after crush injury. Note that in snph KO mice, a higher GAP-43 expression is detected in uninjured DRGs (contralateral) as compared with the WT mice (P = 0.0013). GAP-43 expression is further increased in response to the sciatic nerve injury in snph KO mice (P < 0.0001). Data were analyzed from the total number of neurons indicated within bars from four mice for each genotype and expressed as mean ± SE and by two-way ANOVA followed by Tukey’s post-hoc test. Bars, 50 µm.

Relative expression of GAP-43 after sciatic nerve injury. (A and B) Representative images (A) and quantitative analysis (B) show increased GAP-43 expression in snph KO DRG neurons. snph KO and WT littermates (9 wk old) were subjected to a left-sided sciatic nerve injury. Both injured ipsilateral and uninjured contralateral L5 DRGs of WT and snph KO mice were co-immunostained with antibodies against GAP-43, βIII-tubulin, and DAPI 3 d after crush injury. Note that in snph KO mice, a higher GAP-43 expression is detected in uninjured DRGs (contralateral) as compared with the WT mice (P = 0.0013). GAP-43 expression is further increased in response to the sciatic nerve injury in snph KO mice (P < 0.0001). Data were analyzed from the total number of neurons indicated within bars from four mice for each genotype and expressed as mean ± SE and by two-way ANOVA followed by Tukey’s post-hoc test. Bars, 50 µm.

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