Model of membrane repair. Upon plasma membrane injury, repair proteins localize to the site of damage and actin reorganizes, facilitating membrane repair. Annexins A1, A2, and A6 form a repair cap at the membrane lesion. Dysferlin (DYSF), MG53, BIN1, and EHD participate in forming a shoulder that abuts this repair cap. PIP2 and PS localize adjacent to the repair cap at the shoulder.