Figure 2.
Figure 2. Mitochondrial function and structure in Mffgt hearts. (A) Respiratory control ratio (ADP stimulated/endogenous) of isolated heart mitochondria. A significant decrease is observed at 6 wk (n = 2 samples; two mice/sample) and ≥10 wk (three mutants; five wild types), but not at 4 wk (n = 3 samples; two mice/sample). (B) ATP levels in heart (n = 6). (C) Histochemical stains of mitochondrial respiration complex activities in hearts. Bar, 50 µm. (D) EM of cardiomyocytes. Bars, 10 µm. (E) Mean mitochondrial length. Error bars = SEM. ^, P ≤ 0.05; *, P ≤ 0.01. WT, wild type.

Mitochondrial function and structure in Mffgt hearts. (A) Respiratory control ratio (ADP stimulated/endogenous) of isolated heart mitochondria. A significant decrease is observed at 6 wk (n = 2 samples; two mice/sample) and ≥10 wk (three mutants; five wild types), but not at 4 wk (n = 3 samples; two mice/sample). (B) ATP levels in heart (n = 6). (C) Histochemical stains of mitochondrial respiration complex activities in hearts. Bar, 50 µm. (D) EM of cardiomyocytes. Bars, 10 µm. (E) Mean mitochondrial length. Error bars = SEM. ^, P ≤ 0.05; *, P ≤ 0.01. WT, wild type.

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