ARF6, MT1-MMP, and KIF5B are up-regulated in TNBCs. (A–D) IHC analysis of MT1-MMP, ARF6, KIF5B, and KIF3A in IDCs. Insets show the peritumoral area. Bars: 25 µm; (insets) 10 µm. (E) Hierarchical clustering of the staining patterns of 311 IDC samples based on total KIF3A and KIF5B, and membranous ARF6 and MT1-MMP expression. Data are shown in a table format with the vertical axis listing IDC samples and bars representing antibodies. A color scale, which represents relative staining patterns of each sample, is displayed at the top left corner. Molecular subtypes (HER2, TNBC, and Luminal A + B) and grades are depicted between clusters and dendrogram, with color coding annotated at the bottom left corner.