MK rupture thrombopoiesis responds to acute platelet needs. (A) Time-lapse image of MK rupture mode thrombopoiesis in MKs in 6-wk-old CAG-eGFP mice after administration of a neutralizing anti-CD42b antibody (100 µg/mouse i.p. daily for 3 d; Video 7). (B and C) Platelet counts and MK dynamics in 6-wk-old CAG-eGFP mice treated with anti-CD42b antibody (B) or with thioglycolate, which induces acute peritoneal inflammation (C). n = 8 animals in each group. Bars: (red) 20 µm; (blue) 5 µm. *, P < 0.05 versus day 0.