Model summarizing the different state in telomere clustering throughout mitosis. Schematic representation illustrating the regulation of telomere dissociation throughout mitosis. (left) Telomere foci undergo separation in two discrete steps. Telomere cluster dispersion (up to 6 dots) occurs during metaphase, before chromosome segregation, whereas sister chromatid telomere disjunction (up to 12 dots) is achieved during mid-anaphase. Finally, telomere reclustering occurs during cytokinesis (subsequent G1/S phase). Aurora B is required for telomere dispersion and disjunction. (right) At the level of telomeres, Aurora promotes in metaphase the delocalization of several telomere/subtelomere components, such as shelterin components (brown), Swi6/HP1 (blue), or cohesin Rad21 (green). At anaphase, Aurora favors the loading of condensin (pink). Our model suggests that the delocalization of telomere components such as the shelterin protein Ccq1 promotes telomere dispersion and Aurora-dependent loading of condensin to chromosome arms.