Figure 10.
Figure 10. Model for AnkB interactions with dynactin and axonal cargoes. (left) Proposed model for AnkB coupling of the dynein–dynactin motor complex to cargoes at approximate scale. (center) Homology model of AnkB’s ZU5N-ZU5C-UPA-DD region highlighting binding sites (spheres) for the dynactin subunit p62 and for PtdIns(3)P lipids in membrane cargoes. (right) Molecular docking simulation of PtdIns(3)P binding to ZU5C (dotted lines show interacting residues). Mutated (yellow contour) and additional potential interacting (purple contour) residues are highlighted.

Model for AnkB interactions with dynactin and axonal cargoes. (left) Proposed model for AnkB coupling of the dynein–dynactin motor complex to cargoes at approximate scale. (center) Homology model of AnkB’s ZU5N-ZU5C-UPA-DD region highlighting binding sites (spheres) for the dynactin subunit p62 and for PtdIns(3)P lipids in membrane cargoes. (right) Molecular docking simulation of PtdIns(3)P binding to ZU5C (dotted lines show interacting residues). Mutated (yellow contour) and additional potential interacting (purple contour) residues are highlighted.

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