Model for basal body docking during airway ciliated cell differentiation. Upon centriole replication, CEP164 recruits Cby to the distal appendages. Cby in turn promotes efficient recruitment and fusion of Rab8-positive vesicles to form a ciliary vesicle at the distal end of centrioles. This facilitates docking of basal bodies to the apical membrane. In the absence of Cby, ciliary vesicles fail to form as a result of the inability to recruit sufficient Rab8 vesicles, resulting in compromised basal body docking. CV, ciliary vesicle. See Discussion for details.