RAB4A is amplified in invasive breast cancer. (A) RAB4A is amplified in various tumors. The cBio Cancer Genomics Portal (http://www.cbioportal.org/public-portal/) was queried for RAB4A across various tumor datasets. The alteration frequency, type of alterations of RAB4, availability of mutation analysis, and Copy Number Alteration (CNA) in the various tumor cohorts are shown. (B) RAB4A is, among the RAB family members, the most frequently amplified gene in invasive breast carcinoma. The percentage of each RAB gene amplification in invasive breast carcinoma reported in the Cancer Genome Atlas (TCGA) is shown. Only the genes with a frequency of amplification >5% are shown. (C) RAB4A is overexpressed in breast cancer. Shown are examples of the data of Table S2. Circled areas are enlarged below. Bars, 100 µm.