Figure 8.
Figure 8. Genetic loss of TRIM9 leads to aberrant axon branching within and thickening of the corpus callosum. (A) Coronal sections through corpus callosum from adult TRIM9+/+ and TRIM9−/− mice stained for nissl substance. Lines denote callosal thickness measurements. Graph shows quantitation of callosal thickness; n = 5 mice/genotype; **, P < 0.05 obtained from t test. (B) Inverted maximal projections of Thy1-GFP/TRIM9+/+ and TRIM9−/− corpus callosum sections. Arrowheads denote branch points. (B′) Inset shows an example of a branch. Video 6. (C) Quantitation of axonal branch points in 3-wk-old littermates; n = 3 mice/genotype. P-values obtained from t test. (D) Example images used in quantitation of the number of GFP-expressing axons crossing the midline in Thy1-GFP/TRIM9+/+ and Thy1-GFP/TRIM9−/− brains. Error bars show SEMs.

Genetic loss of TRIM9 leads to aberrant axon branching within and thickening of the corpus callosum. (A) Coronal sections through corpus callosum from adult TRIM9+/+ and TRIM9−/− mice stained for nissl substance. Lines denote callosal thickness measurements. Graph shows quantitation of callosal thickness; n = 5 mice/genotype; **, P < 0.05 obtained from t test. (B) Inverted maximal projections of Thy1-GFP/TRIM9+/+ and TRIM9−/− corpus callosum sections. Arrowheads denote branch points. (B′) Inset shows an example of a branch. Video 6. (C) Quantitation of axonal branch points in 3-wk-old littermates; n = 3 mice/genotype. P-values obtained from t test. (D) Example images used in quantitation of the number of GFP-expressing axons crossing the midline in Thy1-GFP/TRIM9+/+ and Thy1-GFP/TRIM9−/− brains. Error bars show SEMs.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal