Proposed model for the p120–CLASP2 interaction at AJs in epidermal basal progenitors. A scheme of the stratified epidermis is shown, and the magnified area illustrates the microtubule connections with cell adhesions in basal and suprabasal layers. CLASP2 is enriched in basal progenitors, where it targets MTs plus ends to AJs via p120. Nezha localizes in the suprabasal differentiated layers of the epidermis, probably interacting with p120. DP, desmoplakin.