RCP-dependent α5β1 recycling regulates the localization of RacGAP1 and downstream signaling to RhoGTPases. (A) α5β1 trafficking is suppressed by αvβ3 or the transcriptional activity of p63, and Rac signaling predominates at the leading edge. (B) Inhibition of αvβ3 or expression of gain-of-function mutant p53 promotes the association of RCP with α5β1, recruitment of EGFR1, and subsequent recycling. Production of PA by DGK-α within the tips of pseudopods recruits RCP–α5β1/EGFR1 vesicles and localizes downstream signaling via PKB/Akt. Here, PKB/Akt phosphorylates RacGAP1, allowing its recruitment to IQGAP1, providing a platform for the inactivation of Rac and activation of RhoA to promote pseudopod extension and invasion in FN-rich ECM. P, phosphorylation.