Figure 6.
Figure 6. Cx3cr1-GFP–expressing macrophages use both MR and uPARAP for the cellular uptake of collagen in vivo. (A) Percentage of collagen-internalizing GFP-negative and GFP-positive cells from Cx3cr1-GFP transgenic mice that are Mrc1- and Mrc2-sufficient (referred to as wild type; n = 4), Mrc1−/− (n = 4), or Mrc2−/− (n = 4) mice. All mice were injected with fluorescent collagen. *, P < 0.05; and **, P < 0.01 relative to wild-type Cx3cr1-GFP transgenic mice (Student’s t test, two tailed). Error bars show means ± SD. (B–D) Representative low-magnification image of the dermis of a collagen-injected Cx3cr1-GFP transgenic wild-type mouse (B) and representative high-magnification image of the dermis of collagen-injected Cx3cr1-GFP transgenic wild-type mice (C) and Mrc1−/− mice (D). Arrows show examples of internalized collagen. Bars: (B) 50 µm; (C) 10 µm; (D) 8 µm.

Cx3cr1-GFP–expressing macrophages use both MR and uPARAP for the cellular uptake of collagen in vivo. (A) Percentage of collagen-internalizing GFP-negative and GFP-positive cells from Cx3cr1-GFP transgenic mice that are Mrc1- and Mrc2-sufficient (referred to as wild type; n = 4), Mrc1−/− (n = 4), or Mrc2−/− (n = 4) mice. All mice were injected with fluorescent collagen. *, P < 0.05; and **, P < 0.01 relative to wild-type Cx3cr1-GFP transgenic mice (Student’s t test, two tailed). Error bars show means ± SD. (B–D) Representative low-magnification image of the dermis of a collagen-injected Cx3cr1-GFP transgenic wild-type mouse (B) and representative high-magnification image of the dermis of collagen-injected Cx3cr1-GFP transgenic wild-type mice (C) and Mrc1−/− mice (D). Arrows show examples of internalized collagen. Bars: (B) 50 µm; (C) 10 µm; (D) 8 µm.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal