Figure 8.
![Figure 8. Model of hGAAP-dependent control of cell adhesion and migration. hGAAP both stimulates loss of Ca2+ from the Golgi/ER, thereby activating SOCE, and it promotes activation of SOCE by empty stores. The resulting localized increase in [Ca2+]i near the plasma membrane stimulates calpain 2 activity, leading to increased turnover of focal adhesions. This in turn leads to increased speed of cell spreading and more rapid migration. See text in Results and Discussion for further details.](https://cdn.rupress.org/rup/content_public/journal/jcb/202/4/10.1083_jcb.201301016/5/jcb_201301016r_fig8.jpeg?Expires=1771572527&Signature=Wa0qERhWFRmKP2A9tE3L8ndqLEVAaVJYixrjPkiNtEFqQ6Yapt-LDqkUpeIVd7WSBda2E9vx7NbhWM6ERYhqeMSmQGgSsTGRCi-z0oe~jrUu4aMShY3Z8D36B1jFTzqQN1tpZYk6pl4xAOLNloqsEqCPBpbEtTGxpdNodqpN6VNgmU8R7hgjl3fezXer5GInFR0MPPl9jJ1NXog-~cwq~w770HRSHQuhwkZ5DDwtZ6oH9QPeSCJTLi3e8vKOfFB0wOloqdqIMzwr548wALNwEVAelvSQuK9rRUFRnRIky1W-PLK0SSGsQkuIMX0l7FSmrOw04kdTvU6CAcZEtdZ7Fg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Model of hGAAP-dependent control of cell adhesion and migration. hGAAP both stimulates loss of Ca2+ from the Golgi/ER, thereby activating SOCE, and it promotes activation of SOCE by empty stores. The resulting localized increase in [Ca2+]i near the plasma membrane stimulates calpain 2 activity, leading to increased turnover of focal adhesions. This in turn leads to increased speed of cell spreading and more rapid migration. See text in Results and Discussion for further details.
