Figure 7.
Figure 7. ICAP-1–deficient mice present dilated, more branched and tortuous blood vessels. (A) Mesenteric veins of ICAP-1−/− mice were dilated and more branched than in their wild-type littermates. Bar, 5 mm. (B) Quantification of the number of final branches connecting the intestine per mesenteric vein. Points correspond to the number of branches of an individual vein and horizontal bars are the means per genotype (ICAP-1+/+, n = 5 mice from five litters; ICAP-1−/−, n = 4 mice from three litters). *, P < 0.05. (C) Projections of confocal z-stacks of ear whole-mount staining of blood vessels with PECAM. Bar, 100 µm. (D) Histogram of the distribution of blood vessel diameter categories (ICAP-1+/+, n = 4 mice from three litters; ICAP-1−/−, n = 5 mice from two litters). (E) Projections of confocal z-stacks of ear whole-mount staining of blood vessels with PECAM, smooth muscle actin (SMA), and desmin. Bar, 10 µm.

ICAP-1–deficient mice present dilated, more branched and tortuous blood vessels. (A) Mesenteric veins of ICAP-1−/− mice were dilated and more branched than in their wild-type littermates. Bar, 5 mm. (B) Quantification of the number of final branches connecting the intestine per mesenteric vein. Points correspond to the number of branches of an individual vein and horizontal bars are the means per genotype (ICAP-1+/+, n = 5 mice from five litters; ICAP-1−/−, n = 4 mice from three litters). *, P < 0.05. (C) Projections of confocal z-stacks of ear whole-mount staining of blood vessels with PECAM. Bar, 100 µm. (D) Histogram of the distribution of blood vessel diameter categories (ICAP-1+/+, n = 4 mice from three litters; ICAP-1−/−, n = 5 mice from two litters). (E) Projections of confocal z-stacks of ear whole-mount staining of blood vessels with PECAM, smooth muscle actin (SMA), and desmin. Bar, 10 µm.

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