Fluorescent images of a multilobed AG depict relationships of fissures, sinuses, and crypts within the irregular stromal cavernous space network. (A) Multichannel images of a multilobed AG, shown in cross section, demonstrate its irregular morphology. (B) Cropped images of one edge show multiple indentations at the capsular surface. (C) The larger indentations with vimentin-positive lining delineate meningothelium-coated fissures, which impart distinct lobes. (D) Smaller surface apertures represent sinuses and crypt openings that are shown in communication with the periapical space. (E and F) Internal CD68⁺ macrophages (C and E) and sinuses and crypts (F) are depicted in multichannel images. (A–F) Green/FITC, vimentin or CD68; red/CY3, pan-collagen; white/CY5, CD68; blue, DAPI; DIC, differential interference contrast. Scale bars: (A) 100 µm; (B) 50 µm; (C) 25 µm; (D–F) 10 µm. Single asterisks (*) represent primary fissures. Double asterisks (**) represent secondary fissures that branch off of primary fissures. Arrows represent sinus and crypt spaces. Images are confocal z-stacks. Note that internal cavernous spaces are formed by smaller sinuses and larger, lake-like crypts that communicate directly with the periapical region at multiple foci of surface capsular deficiency. Data are representative of multilobed morphology from eight old decedents, studied on >75 independent experiments.