Clonal expansion of Th17-like cluster and Treg cells infiltrating the inflamed joint of ZAC mice. (A) TCR repertoire diversity of naive or effector Tconv and Treg cells from the spleen of WT and ZAC mice in Fig. 4 A, expressed as inverse Simpson index. (B) TCR counts of top 20 frequent clonotypes in splenic Tconv and Treg cells from two WT and two ZAC mice (see also Table S1). (C) TCR repertoire diversity of each cluster in Fig. 4 A, color-coded by predominant composition in each cluster. (D and E) TCR clonotype tracking of ZAC Tconv (D) and Treg cells (E) in the spleen, dLN, and inflamed joint of the same mouse (ZAC mouse #1). Cluster 6 (spleen) is also shown in D (see also Fig. S3, D and E, and Table S1). (F) TCR clonotype overlaps between splenic Tconv and Treg cells in WT and ZAC mice (two mice each). (G) ZAC Tconv and Treg cells possessing overlapped TCR clonotypes (red dots) in UMAP clusters, shown in Fig. 4 A.