iRegulon analysis of transcription factor–binding sites enriched in RNA from control subjects compared with SARS-CoV-2–positive patients. Related to Fig 1. (A) Transcription factor (TF) motifs/track–binding sites enriched in NP RNA from control subjects. Bars show strength of association (normalized enrichment score [NES]) with motifs/tracks and associated transcription factors. Transcription factors associated with regulation of neuronal tissue–specific genes are highlighted in red. (B and C) Targets of transcription factors REST (B) and POU3F2 (C) enriched in NP RNA from control subjects. Red text indicates targets previously shown to be more highly expressed in olfactory compared with respiratory epithelium. Asterisks indicate transcripts also enriched in olfactory sensory neurons (olfactory epithelium, respiratory epithelium, and olfactory sensory neuron expression data are from Olender et al., 2016).