Evidence of neuroinvasion in postmortem COVID-19 patient brains (caudate). FFPE sections of brain tissue from COVID-19 patients were stained using H&E or anti–SARS-CoV-2-spike antibody. (A) Images of regions of the caudate of patient 1. White numbers indicate unaffected regions, and black numbers indicate regions with infected cells. Dotted lines around 1 and 2 indicate ischemic infarcts with virus staining. (B) Images of regions of the caudate of patient 2. White numbers indicate unaffected regions, and black numbers indicate regions with infected cells. Dotted circles indicate ischemic infarcts. (C) Images of regions of the caudate of patient 3. White numbers indicate unaffected regions, and black numbers indicate regions with infected cells. Dotted lines around 1 and 4 indicate ischemic infarcts with virus staining. Images 1, 4, and 5 are shown in Fig. 4.(D) Example images from control patient brains. Scale bar = 200 µm for zoomed-out images and 20 µm for zoomed-in images.