Figure S2.
SARS-CoV-2 infection depends on hACE2.(A) Expression levels of ACE2, TMPRSS2, and NRP1 from single-cell RNA-seq data. (B) Correlation of ACE2, TMPRSS2, and NRP1 expression to percentage of cells infected in each cluster.(C) Imaging of postmortem COVID-19 patient brains stained with ACE2 and NEUN. Scale bar = 25 µm.(D) Uncropped images of ACE2 antibody–treated organoids shown in Fig. 3 B. Scale bar = 100 µm. (E) Uncropped images of CSF-treated organoids shown in Fig. 3 E. All experiments were performed with unique organoid,n = 4 per condition, with images fromn = 12 cortical regions with two IPSC lines. Experiments were performed twice for reproducibility. Scale bar = 100 µm.

SARS-CoV-2 infection depends on hACE2. (A) Expression levels of ACE2, TMPRSS2, and NRP1 from single-cell RNA-seq data. (B) Correlation of ACE2, TMPRSS2, and NRP1 expression to percentage of cells infected in each cluster.(C) Imaging of postmortem COVID-19 patient brains stained with ACE2 and NEUN. Scale bar = 25 µm.(D) Uncropped images of ACE2 antibody–treated organoids shown in Fig. 3 B. Scale bar = 100 µm. (E) Uncropped images of CSF-treated organoids shown in Fig. 3 E. All experiments were performed with unique organoid,n = 4 per condition, with images fromn = 12 cortical regions with two IPSC lines. Experiments were performed twice for reproducibility. Scale bar = 100 µm.

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