Figure S2.
Forskolin protects SCD mice from VOE. SCD mice were treated with forskolin for 5 d and challenged in the TNFα/surgical trauma–induced VOE model. (A–C) Number of adherent leukocytes (A), number of rolling leukocytes (B), and blood flow rate (C) in in the postcapillary collecting venues of cremaster muscle in vehicle-treated SCD mice (n = 32 venules from six mice) and forskolin-treated SCD mice (n = 29 venules from six mice) analyzed by intravital microscopy.(D) Survival time of vehicle-treated SCD mice (n = 6) and forskolin-treated SCD mice (n = 6) in TNFα-induced acute vaso-occlusion. Error bars, mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Data analyzed using unpaired Student’s t test in A–C and Mantel–Cox test (log-rank) for the survival analysis in D.

Forskolin protects SCD mice from VOE. SCD mice were treated with forskolin for 5 d and challenged in the TNFα/surgical trauma–induced VOE model. (A–C) Number of adherent leukocytes (A), number of rolling leukocytes (B), and blood flow rate (C) in in the postcapillary collecting venues of cremaster muscle in vehicle-treated SCD mice (n = 32 venules from six mice) and forskolin-treated SCD mice (n = 29 venules from six mice) analyzed by intravital microscopy.(D) Survival time of vehicle-treated SCD mice (n = 6) and forskolin-treated SCD mice (n = 6) in TNFα-induced acute vaso-occlusion. Error bars, mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Data analyzed using unpaired Student’s t test in A–C and Mantel–Cox test (log-rank) for the survival analysis in D.

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