Figure S1.
Depletion of nociceptors and CGRP administration have no effect on the degree of anemia in SCD mice.(A) Number of RBCs in the peripheral blood of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(B) Plasma hemoglobin concentrations of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(C) Spleen weights of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(D) Number of RBCs in vehicle-treated SCD mice (n = 5) and CGRP-treated SCD mice (n = 5). (E) Spleen weights of vehicle-treated SCD mice (n = 5) and CGRP-treated SCD mice (n = 5). Error bars, mean ± SEM. Data represent at least two independent experiments analyzed using unpaired Student’s t test. ns, not significant.

Depletion of nociceptors and CGRP administration have no effect on the degree of anemia in SCD mice. (A) Number of RBCs in the peripheral blood of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(B) Plasma hemoglobin concentrations of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(C) Spleen weights of SCD → iDTA mice (n = 8) and SCD →Trpv1-Cre; iDTA mice (n = 4).(D) Number of RBCs in vehicle-treated SCD mice (n = 5) and CGRP-treated SCD mice (n = 5). (E) Spleen weights of vehicle-treated SCD mice (n = 5) and CGRP-treated SCD mice (n = 5). Error bars, mean ± SEM. Data represent at least two independent experiments analyzed using unpaired Student’s t test. ns, not significant.

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