TREM2^R47H enhances APOE expression through chromatin modulation. (A–C) Genome browser schematic and peak scans comparing mRNA levels and genomic epigenetic modification at the APOE (A), LPL (B), and APOC1 (C) locus; RNA-seq and normalized signals for ATAC-seq, H3K4me3, and H3K27ac ChIP-seq are shown in representative assays from hMGL as indicated. Chr, chromosome.