Figure 2.
Integrative multi-omic analysis demonstrates convergence at the APOE locus in mutant hMGLs.(A–D) APOE pathway network in individual hMGL lines. OmicsIntegrator network branches containing APOE is depicted from multi-omic TREM2 KO (A), TREM2R47H (C), SORL1 KO (B), and SORL1A528T (D) hMGL datasets. Color scheme for nodes identified by a particular analytical dataset is shown in A; node and font size are scaled according to identification across multi-omic datasets. APOE is intentionally marked with an increased font size, and adjacent nodes are highlighted. Gray nodes depict node inserts applied by the OmicsIntegrator algorithm to connect adjacent networks.

Integrative multi-omic analysis demonstrates convergence at the APOE locus in mutant hMGLs. (A–D) APOE pathway network in individual hMGL lines. OmicsIntegrator network branches containing APOE is depicted from multi-omic TREM2 KO (A), TREM2R47H (C), SORL1 KO (B), and SORL1A528T (D) hMGL datasets. Color scheme for nodes identified by a particular analytical dataset is shown in A; node and font size are scaled according to identification across multi-omic datasets. APOE is intentionally marked with an increased font size, and adjacent nodes are highlighted. Gray nodes depict node inserts applied by the OmicsIntegrator algorithm to connect adjacent networks.

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