Figure 4.
Figure 4. Tracer outflow to spine-draining LNs is minor in comparison to outflow to cranial-draining LNs. (A) Representative pictures of tracer within deep cervical, mandibular, and iliac/caudal mesenteric LN groups 60 min after P40D680 i.c.v. infusion in ket/med and awake mice. Dashed lines were drawn using Prox1-GFP signals to indicate the location of LNs with low P40D680 signal. Scale bars, 1 mm. (B) Fluorescence intensity of the three LN groups at 60 min in ket/med and awake mice. Data are mean ± SD and representative of two independent experiments (n = 5 each group, one-way ANOVA with Tukey’s post hoc analysis; **, P < 0.01; ***, P < 0.001).

Tracer outflow to spine-draining LNs is minor in comparison to outflow to cranial-draining LNs. (A) Representative pictures of tracer within deep cervical, mandibular, and iliac/caudal mesenteric LN groups 60 min after P40D680 i.c.v. infusion in ket/med and awake mice. Dashed lines were drawn using Prox1-GFP signals to indicate the location of LNs with low P40D680 signal. Scale bars, 1 mm. (B) Fluorescence intensity of the three LN groups at 60 min in ket/med and awake mice. Data are mean ± SD and representative of two independent experiments (n = 5 each group, one-way ANOVA with Tukey’s post hoc analysis; **, P < 0.01; ***, P < 0.001).

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