Redepletion of γδ T cells confers reprotection in IMQ-induced psoriasis. (A) For redepletion of γδ T cells, mice were treated twice with DTx at 9 wk and 3 d, before IMQ treatment. Mice of the recovered group were treated only once with DTx at 9 wk before IMQ treatment. (B) Littermates of Tcrd-GDL mice were treated as described in A. Mean frequency of cervical LN (cLN) γδ T cells of d8 IMQ-treated Tcrd-GDL mice. One dot represents one mouse; one experiment representative of two is shown. (C) Ear thickness over time of indicated groups. IMQ treatment started 9 wk after first γδ T cell depletion. Shown are pooled data from two independent experiments with each two to four mice per group, mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, not significant.