Figure 4. DCs dynamically cross talk... | Rockefeller University Press

Figure 4.

$Figure 4. DCs dynamically cross talk with MCs upon skin inflammation. Intravital multiphoton imaging of DCGFP/MCRFP mouse ear skin before and after DNFB administration, 3D rendered z-stack. Bars, 40 µm. (A) Longitudinal and side-matched imaging. (B) Dashed line indicates a blood vessel and refers to Videos 2, 3, and 4. (C) Computed quantification of the fraction of MCs interacting with dDCs in randomly chosen z-stacks before (n = 102) and after DNFB administration (n = 30 each). Histograms represent the normalized number of z-stacks with a certain fraction of interacting MCs. **, P < 0.01.$

DCs dynamically cross talk with MCs upon skin inflammation. Intravital multiphoton imaging of DC^GFP/MC^RFP mouse ear skin before and after DNFB administration, 3D rendered z-stack. Bars, 40 µm. (A) Longitudinal and side-matched imaging. (B) Dashed line indicates a blood vessel and refers to Videos 2, 3, and 4. (C) Computed quantification of the fraction of MCs interacting with dDCs in randomly chosen z-stacks before (n = 102) and after DNFB administration (n = 30 each). Histograms represent the normalized number of z-stacks with a certain fraction of interacting MCs. **, P < 0.01.