IL-1β released from radiosensitive cells acts on IL-1R1 expressed on radioresistant cells to induce EAE. (A–F) The clinical course of EAE was analyzed in mice constitutively lacking IL-1R1 (A; n = 8), IL-1α (B; n = 6), or IL-1β (C; n = 10) and their WT controls (n = 21), as well as in bone marrow chimeric mice (D–F; n = 6–8/group). Results are expressed as the daily mean clinical score ± SEM for one out of two independent experiments (details for all mice are provided in Table 1). **, P < 0.01; ***, P < 0.001, compared with WT (A–C) or WT → WT mice (D–F), two-way repeated-measures ANOVA followed by a Bonferroni post-hoc test.