Figure 3.
Figure 3. Adenosine signaling through A2b specifically regulates HSPC development. (A–H) Control or A2b MO–injected embryos stained for runx1 in the AGM at 36 hpf (A and B), runx1/cmyb in the CHT at 60 hpf (C and D), cmyb in the CHT (E and F), and RAG1 in the thymus (red arrows in G and H) at 4.5 dpf. (I–X) Control or A2b MO–injected embryos stained for vasculature (flk1; I and J), dorsal aorta (ephrinB2; K and L), pronephros (cdh17; M and N), and somite (myoD; O and P), primitive hematopoiesis (gata1 and scl; Q–T), and cmyb and runx1 (U–X) at the developmental stages indicated. In I and J, red arrowheads mark intersegment staining. Bars, 100 µm.

Adenosine signaling through A2b specifically regulates HSPC development. (A–H) Control or A2b MO–injected embryos stained for runx1 in the AGM at 36 hpf (A and B), runx1/cmyb in the CHT at 60 hpf (C and D), cmyb in the CHT (E and F), and RAG1 in the thymus (red arrows in G and H) at 4.5 dpf. (I–X) Control or A2b MO–injected embryos stained for vasculature (flk1; I and J), dorsal aorta (ephrinB2; K and L), pronephros (cdh17; M and N), and somite (myoD; O and P), primitive hematopoiesis (gata1 and scl; Q–T), and cmyb and runx1 (U–X) at the developmental stages indicated. In I and J, red arrowheads mark intersegment staining. Bars, 100 µm.

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