Figure 9.
siVCAM-1 treatment reduces inflammation after coronary ligation in C57/Bl6 wild type mice. Lin− CD11b+ infarct myeloid cells, monocytes and macrophages by flow cytometry (A) and CD11b+ infarct area quantified by immunohistochemistry (B; n = 4–5). The scale bar denotes 100 µm. Quantification of proliferating and apoptotic (C) macrophages in the infarct (n = 4–5 per group). Lin−CD11b+ myeloid cells and monocytes in (D) blood, (E) bone marrow, and (F) spleen (n = 4–5). This figure shows data from one of two independent experiments. Data are mean ± SEM. Significance was determined by Mann-Whitney test. *, P < 0.05.