CD115 knockdown reduces inflammation in the infarct after coronary ligation. (A) Experimental design. (B) Myeloid cells, macrophages and monocytes in the infarct (n = 3–7). (C) Histological quantification of Ly-6G and CD11b staining in the infarct (n = 5). Bar, 100 µm. (D) Circulating myeloid cells on day 4 after MI (n = 5). Data were pooled from 3 (B) and 2 (C&D) independent experiments. Data are mean ± SEM. Significance was determined by Mann-Whitney test and one-way ANOVA. *, P < 0.05, **, P < 0.01.