Figure 7.
Figure 7. CD115 knockdown reduces inflammation in atherosclerosis. (A) Experimental design. (B) Enumeration of LSKs and HSCs in the spleens of ApoE−/− mice after CD115 knockdown. Representative FACS plots show percentage of monocytes in the blood (C), and macrophages and monocytes in the aorta (D) in ApoE−/− mice treated with either control or CD115 siRNA. The bar graphs show levels of monocytes and Ly-6chigh monocytes in the blood (C) and macrophages and monocytes in the aorta (D) after CD115 knockdown (n = 4–5 per group). (E) Representative images showing Masson staining of the aortic root. The bar graphs depict quantification of total plaque size, fibrous cap thickness, and necrotic core area (n = 5 per group). Experiments were performed in duplicate. Bar, 30 µm. All data are shown as mean ± SEM. Statistical significance was determined by Mann-Whitney test. *, P < 0.05; **, P < 0.01.

CD115 knockdown reduces inflammation in atherosclerosis. (A) Experimental design. (B) Enumeration of LSKs and HSCs in the spleens of ApoE−/− mice after CD115 knockdown. Representative FACS plots show percentage of monocytes in the blood (C), and macrophages and monocytes in the aorta (D) in ApoE−/− mice treated with either control or CD115 siRNA. The bar graphs show levels of monocytes and Ly-6chigh monocytes in the blood (C) and macrophages and monocytes in the aorta (D) after CD115 knockdown (n = 4–5 per group). (E) Representative images showing Masson staining of the aortic root. The bar graphs depict quantification of total plaque size, fibrous cap thickness, and necrotic core area (n = 5 per group). Experiments were performed in duplicate. Bar, 30 µm. All data are shown as mean ± SEM. Statistical significance was determined by Mann-Whitney test. *, P < 0.05; **, P < 0.01.

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